Endocrine Abstracts

In the current study, we aimed to illustrate determinants of VDR gene expression in visceral and subcutaneous adipose tissues among obese and morbidly obese adults. We gathered visceral and subcutaneous adipose tissues during an elective abdominal surgery form 33 morbidly obese (body mass index (BMI) >40 kg/m2) and 23 obese (BMI = 30–40 kg/m2) participants who were free of diabetes. Before the surgery, dietary intake, physical activity, anth...

Background: By focusing on nutrition transition in the Middle East and North Africa, this study aim to investigate the general structure and secular trend of dietary patterns extracted from the Tehran Lipid and Glucose Study (TLGS) and adherence to these dietary patterns among Iranian population from 2006 till 2017.Methods: We investigated on four examination surveys of TLGS including survey 1 (2006–2008), survey 2 (2009–2011), survey 3 (2012...

Objectives: To measure linear growth of patients and the magnitude of catch-up growth and changes and IGF1 concentration.Design: This prospective study recorded the anthropometric data and measured the IGF1 of 32 infants and children with congenital acyanotic heart disease (CAHD) with left to right shunt (14 VSD, 10 ASD, and 8 PDA) without heart failure, and 15 with cyanotic heart disease (CCHD) before (B) and a year after (A) surgical or catheter interv...

Hypoadrenalism and bilateral adrenal haemorrhage are rare manifestations of lymphoma. We present a case of diffuse large B cell non-Hodgkins lymphoma (NHL) in whom the main manifestations of relapse included hypoadrenalism and then bilateral adrenal haemorrhage.A 75-year-old male presented with a 2-week history of severe left sided abdominal pain. He was known to have NHL predominantly involving the right maxillary sinus, which had been treated with chem...

It is now generally acknowledged that local tissue concentrations of cortisol and cortisone are modulated by site-specific actions of 11β-hydroxysteroid dehydrogenase (11β-HSD) isoenzymes 1 and 2. Cortisone, the inactive metabolite of cortisol is produced by type 2 11β-HSD. To assess 11β-HSD type 1 and 2 activity, the cortisone/cortisol ratio has to be accurately determined. Immunoassays to measure cortisone levels are not widely available and tend to lack ...

Glycyrrhetinic acid (GA) has diverse in vitro effects as an inhibitor of 11beta hydroxysteroid dehydrogenase (11HSD), 5alpha reductase and hormone receptor binding. However, in vivo GA studies have focussed on the hypertensive effects associated with the syndrome of apparent mineralocorticoid excess (SAME) in which 11HSD inhibition allows glucocorticoid hormones to bind inappropriately to MR and subsequent decreased aldosterone synthesis. Here we consider whether...

Introduction and aim: Leptin is a hormone that mainly expressed and secreted in adipose tissues and has a number of important effects on regulation of body weight, energy expenditure, and thermogenesis. High intake of n-3 polyunsaturated fatty acids (PUFA) promotes reduced plasma concentration of triacylglycerol, glycerol, and free fatty acids, as well as metabolism of the epididymis. The aim of current study was to examine the association of n-3PUFA on leptin gene expression ...

Background and objective: Adipose tissue where energy homeostasis is regulated is now considered an endocrine organ. miRNAs may contribute to the regulation of energy balance and metabolic homeostasis, by controlling a wide range of metabolic pathways. miR-143 and miR-34a are the best studied among the miRNAs linked to adipose tissue regulation. Dietary intake, among many other environmental factors, is a key player that can induce epigenetic changes. The aim of the study was ...

Introduction: Adipocytokines secreted by adipose tissue are suggested to play a role in the development of obesity-related complications. Leptin is mainly produced and secreted by adipose tissue and appears as an important regulator of energy balance. The relationship between leptin levels and energy expenditure remain unclear. Energy expenditure related to physical activity (PA) is the most variable part of total energy expenditure. There is some evidence tha...

Introduction: The fat mass and obesity-associated gene (FTO) has been shown to be associated with obesity and might be affected by dietary factors. Long-term dietary intake of amino acids are capable to change adipose tissue metabolism through regulation of FTO production. This study aims to examining the association of dietary acidic and basic amino acids (AAs) with FTO gene expression in subcutaneous and visceral adipose tissues among non-diabetic adults.<p class="abstex...